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.: Lima, Deolinda

Schools Committee Member

Full Professor
Deolinda Lima
Head of Department
Laboratory of Molecular Cell Biology
Faculty of Medicine of the University of Oporto
Phone: 351 22 5513654
Fax: 351 22 5513655
E-mail: limad@med.up.pt

Major research interests

Pain - Anatomy and physiology of the pain processing system.
The work is focused on structural, neurochemical and electrophysiological charaterization of the neuronal circuitry at the spinal level and within the endogenous pain control system, and the plastic changes occuring upon the establishment of chronic pain.
Present research interests include: Electrophysiological behaviour of populations of nociceptive neurones through multielectrode simultaneous recordings in real time.
Molecular probes for the different kinds of spinal neurones.
Genetic and epigenetic factors of the embryonic development of the nociceptive system.
Manipulation of the endogenous pain control system by the use of gene therapy.

Present position

Full Professor

Curriculum Vitae

Education

1994 Habilitation
1989 PhD
1983 Master
1975 MD

Professional and academic career

from 2007
Vice President of the Scientific Council of the Medical Faculty of the University of Porto
from 2003
Head of the IBMC Research Group "Morphophysiology of the Somatosensory System
from 2000
Full Professor Medical Faculty of the University of Porto
from 1992 to 2000
Associate Professor Medical Faculty of the University of Porto
from 1989 to 1992
Auxiliary Professor Medical Faculty of the University of Porto
from 1983 to 1989
Assistant Professor Medical Faculty of the University of Porto
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Past President of the Portuguese Neuroscience Society (SPN)
Past officer at the NENS Committee
Proponent of the Lisbon FENS Forum
Local Organizing Committee of the 4th FENS Forum
Local Organizer of the Ofir FENS Summer Schools
In charge of the Brain awareness week for the North Portugal until 2006
EDAB member
Local organization of several SPN Neuroscience Meetings
Member of the Scientific Programme Committee of several National and International
Neuroscience and Pain meetings
Director of the Doctoral Program in Neuroscience of the University of Oporto
Promoter of the scientific program of three FENS Ofir Summer Schools

Honors and Awards

1990 Prize Boa Esperança - Portuguese Government
1992 Prize "Fundaçăo Oriente" - Orient Foundation, Portugal
1994 Bial Prize (Honour award)
1996 Bial Prize (Honour award)
2000 Portuguese Grunenthal Prize for Pain Research - Grunenthal Foundation
2003 Portuguese Grunenthal prize for Pain Research - Grunenthal Foundation (Honour award)
2003 Best Poster of the fourth EFIC-Pain Congress in Europe European Federation of IASP Chapters
2006 Portuguese Grunenthal Prize for Pain Research - Grunenthal Foundation

Selected Publications

  • 1. Xu, Y., Lopes, C., Qian, Y., Liu, Y., Cheng, L., Goulding, M., Turner, E., Lima, D., Ma Q. Tlx1 and Tlx3 Coordinate specification of dorsal horn pain-modulatory peptidergic neurons. The Journal of Neuroscience, 28:4037-4046 (2008)
  • 2. Pais Vieira, M., Lima, D. & Galhardo, V. Orbitofrontal cortex lesions disrupt risk assessment in a novel serial decision-making task for rats. Neuroscience, 145: 225-231 (2007)
  • 3. Rebelo, S., Chen, Z-F., Anderson, D. J. and Lima, D. Involvement of DRG11 in the development of the primary afferent nociceptive system. Molecular Cell Neuroscience, 33:236-246 (2006)
  • 4. Castro AR, Pinto M, Lima D e Tavares I. Imbalance between the expression of NK1 and GABAB receptors in nociceptive spinal neurons during secondary hyperalgesia: a c-fos study in the monoarthritic rat. Neuroscience, 132: 905-916 (2005)
  • 5. Dugast, C., Almeida, A. and Lima, D. The medullary dorsal reticular nucleus (DRt) enhances the responsiveness of spinal nociceptive neurons to peripheral stimulation in the rat. Europ. J. Neurosci., 18: 580-588 (2003)
  • 6. Galhardo, V., Apkarian, A. V. and Lima, D. Peripheral inflammation increases the functional coherency of spinal responses to tactile but not nociceptive stimulation. J. Neurophysiol., 88: 2096-2103 (2002)
  • 7. Lima, D. and Almeida, A. The medullary dorsal reticular nucleus as a pronociceptive centre of the pain control system. Prog. Neurobiol. 66, 81-108 (2002)
  • 8. Chen, Z-F., Rebelo, S., White, F., Malmberg, A. B., Baba, H., Lima, D., Woolf, C. J., Basbaum, A. I., and Anderson, D. The paired homeodomain protein DRG11 is required for the projection of cutaneous sensory afferent fibers to the dorsal spinal cord. Neuron 31: 5973 (2001)
  • 9. Tavares I, Lima D and Coimbra A. The ventrolateral medulla of the rat is connected with the spinal cord dorsal horn by an indirect descending pathway relayed in the A5 noradrenergic cell group. J. Comp. Neurol. 374: 84-95 (1996)
  • 10. Lima D and Coimbra A. The spinothalamic system of the rat: structural types of retrogradely labelled neurons in the marginal zone (lamina I). Neuroscience 27: 215-230 (1988)
  • 11. Lima D and Coimbra A. A Golgi study of the neuronal population of the marginal zone (lamina I) of the rat spinal cord. J. Comp. Neurol. 244: 53-71 (1986)