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Novak, Michael
Schools Committee Member
Univ. Prof., MDV, PhD, DSc, Dr.h.c.
Michael Novak
Axon Neuroscience
Rennweg 95b
A-1030 Vienna, Austria
Personal
Date and place of birth: September 29 1947, Bratislava, Slovak Rep.
Citizenship: Slovak
Specialisation
Main field:
Molecular Neurobiology
Neurosciences
Other field:
Molecular Immunology
Current research interest:
Role of tau proteins in Alzheimer's disease pathogenesis
Diagnostic assays for AD and animal models
Engineering of monoclonal antibodies as structural biomedical probes
| Curriculum VitaeEducation (degrees, dates, universities)- M.D.V.
- doctor of vet.medicine 1971, First class honours, University of Veterinary Medicine, Kosice, Slovak Republik
- Ph.D. - 1978
- Univ.Vet.Medicine, Kosice, Slovak Republic, (molecular immunology)
- 1978-1980
- Post doctoral fellow, Slovak Academy of Sciences, Bratislava,Slovak Republik
- 1980-1985
- Group leader, Slovak Academy of Sciences, Bratislava, Slovak Republik
- 1985-1987
- Senior Research Scientist - (24 months)MRC Laboratory of Molecular Biology, Cambridge, England (working with A.Klug/C.Milstein)
- 1988
- MRC Laboratory of Molecular Biology, Cambridge, England (working with sir A.Klug and C.Milstein)
- 1989
- University of Cambridge, Dept. Psychiatry, Cambridge, England (working with sir M.Roth)
- 1990-1994
- MRC Laboratory of Molecular Biology, Cambridge, England (working with sir A.Klug /C.Milstein /sir M.Roth/J.Walker)^
- D.Sc - 1994
- Neurosciences - Slovak Academy of Sciences, Bratislava
- Dr.h.c. - 2007
- University of Veterinary Medicine, Kosice
Career/Employment (employers, positions and dates)- 1978-1980
- Part time Assistant Professor, Dept. Microbiol.Immunology, Univ.Vet.Medicine, Kosice, Slovakia
- 1980-1985
- Associate Professor of Molecular Neurobiol.Immunology, Slovak Academy of Sciences, Bratislava
- 1985-1994
- Senior Research Scientist, MRC, Laboratory of Molecular Biology and Univesity of Cambridge, Cambridge, England
- 1994- 2000
- Visiting Professor of Neurosciences, International School for Advanced Studies (ISAS), Trieste,Italy
- 1995-2000
- International Scholar of Howard Hughes Medical Institute, Maryland, USA
- 1994-
- Foundation Memory, Chairman (Founder)
- 1995-
- Full Professor of Microbiology and Immunology, University of Veteterinary Medicine, Kosice, Slovak Republic
- 1996
- Director (Founder) , Institute of Neuroimmunology, Slovak Academy of Sciences, Bratislava, SK
- 1997-
- Member - Council of Goverment for Science
- 1997-
- Governor of the Slovak Republic for Genetic engineering and biotechnology (ICGEB) in Trieste, Italy
- 1998-
- President (founder) Slovak Alzheimer's Society, member of Alzheimer's Disease International (ADI) and Alzheimer Europe (AE)
- 2005-
- President (co-founder) Slovak Society for Neuroscience
Honours, Awards, Fellowships, Membership of Professional Societies- 1985
- National Prize for Medicine, Bratislava, Slovakia
- 1994 - 1996
- Grant from Human Frontiers Science Organisation, (HFSPO) Strasbourg
- 1995-2000
- Grant from Howard Hughes Medical Institute, Maryland,USA
- 2007
- doctor honoris causa - University of Veterinary Medicine, Kosice
- 2007
- Golden Medal - Slovak Academy of Sciences
Membership- Society for Neuroscience
- Society for Immunology
- New York Academy of Sciences
Member of Editorial Boards- International Journal of Alzheimer's Disease
- Bratislava Medical Journal
- Journal of Alzheimer's Disease
- Cellular and Molecular Neurobiology
| Selected Publications- Zilka N, Minichova Z, Kovac A, Pilipcinec, E, Bugos O, Novak M
'uman misfolded truncated tau protein promotes activation of microglia and leukocyte infiltration in the transgenic rat model of tauopathy.'
J Neuroiimunol 2009, 16-25
- Sevcik J , Skrabana R, Kontsekova E, Novak M
'Structure solution of misfolded conformations adopted by intrinsically disordered Alzheimer's tau protein.'
Protein and Peptide Letters 2009
- Miroslava Korenova, Norbert Zilka, Zuzana Stozicka, Ondrej Bugos, Ivo Vanicky, Michal Novak
'Neuroscale, the battery of behavioral tests with novel scoring system for phenotyping of transgenic rat model of tauopathy'
Journal of Neuroscience Methods. 2009, 177, 108-114
- Mucha R., Bhide M.R., E.B. Chakurkar, M. Novak , Mikula I. sr.
'oll-like receptor tlr1, tlr2 and tlr4 gene mutations and natural resistance to mycobacterium avium subsp. paratuberculosis infection in cattle'
Veterinary Immunology And Immunopathology 2009, 128, 381-388
- Jozef Hanes, Norbert Zilka, Miriam Bartkova, Miroslava Caletkova, Dusan Dobrota, Michal Novak
'Rat tau proteome consists of six tau isoforms: implication for animal models of Alzheimer's disease.'
Journal of Neurochemistry 2009, 108, 1167-1176
- Eva Kontsekova, Natalia Ivanovova, Martina Handzusova, Michal Novak
'Chaperone-like antibodies in neurodegenerative tauopaties: implication for immunotherapy.'
Cellular and Molecular Neurobiology (2009) 29:793-798
- Branislav Kovacech, Norbert Zilka, Michal Novak
'From transgenic tau models to human patients: disease modifying pathways and therapeutic approaches for human tauopathies.'
Acta Neuropathologica (2009) 118:71-86
- Bhide MR, Martina Cepkova, Ivan Mikula jr., Lucia Kisova, Rostislav Skrabana, Michal Novak, Ivan Mikula sr.
'Novel mutations in TLR genes cause hyporesponsiveness to Mycobacterium avium subsp. paratuberculosis infection.'
BMC Genetics 2009, 10:21
- Peter Filipcik, Martin Cente, Gabriela Krajciova, Ivo Vanicky, Michal Novak
'Cortical and hippocampal neurons from truncated tau transgenic rat express multiple markers of neurodegeneration.'
Cellular and Molecular Neurobiology 2009 29: 895-900
- Martin Cente, Peter Filipcik, Stanislava Mandakova, Norbert Zilka, Gabriela Krajciova, Michal Novak
'Expression of a truncated human tau protein induces aqueous-phase free radicals in a rat model of tauopathy - implications for targeted antioxidative therapy '
Journal of Alzheimer's Disease 17 (2009) 913-920
- Andrej Kovac, Monika Zilkova, Maria A. Deli, Norbert Zilka, Michal Novak
'Human truncated tau is using different mechanism from beta-amyloid to damage blood-brain barrier'
ournal of Alzheimer's Disease 2009 volume 18, number 4, (in press)
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